Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Middle East respiratory syndrome and severe acute respiratory syndrome: current therapeutic options and potential targets for novel therapies

J Dyall, R Gross, J Kindrachuk, RF Johnson… - Drugs, 2017 - Springer
No specific antivirals are currently available for two emerging infectious diseases, Middle
East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A …

The role of dysregulated immune responses in COVID-19 pathogenesis

S Tahaghoghi-Hajghorbani, P Zafari, E Masoumi… - Virus research, 2020 - Elsevier
Abstract The coronavirus disease-2019 (COVID-19) which caused by severe acute
respiratory syndrome-related coronavirus (SARS-CoV-2), is a pandemic threat to global …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

A Silva-Cayetano, WS Foster, S Innocentin… - Med, 2021 - cell.com
Background The spread of SARS-CoV-2 has caused a worldwide pandemic that has
affected almost every aspect of human life. The development of an effective COVID-19 …

Viroporins and inflammasomes: a key to understand virus-induced inflammation

NS Farag, U Breitinger, HG Breitinger… - The international journal …, 2020 - Elsevier
Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …

[HTML][HTML] Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation

R Augustine, S Abhilash, A Nayeem, SA Salam… - Chemico-biological …, 2022 - Elsevier
The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that
causes coronavirus disease 2019 (COVID‐19), has had a dramatic negative impact on …

Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome

RC Borges, MS Hohmann… - International Reviews of …, 2021 - Taylor & Francis
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. This novel coronavirus
emerged in China, quickly spreading to more than 200 countries worldwide. Although most …

Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and …

AD Brunaugh, H Seo, Z Warnken, L Ding, SH Seo… - PloS one, 2021 - journals.plos.org
Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-
2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved …

COVID-19 in the elderly people and advances in vaccination approaches

K Dhama, SK Patel, S Natesan, KS Vora… - Human vaccines & …, 2020 - Taylor & Francis
The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of …