Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …

To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …

Highlights•PAH is a progressive pulmonary vascular disease characterized by excessive
pulmonary vasoconstriction and pulmonary vascular remodeling.•Although currently drugs …

Vascular smooth muscle cells (VSMCs) play important roles not only in the physiological
functions of the blood vessels, such as vasoconstriction, vasodilatation and extracellular …

Vascular tissue engineering has the potential to make a significant impact on the treatment
of a wide variety of medical conditions, including providing in vitro generated vascularized …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Rationale: Although not fully understood, the phenotypic transition of vascular smooth
muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the …

The ability to quantify DNA, RNA, and protein variations at the single cell level has
revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses …

Pulmonary arterial hypertension (PAH) is a progressive incurable condition that is
characterized by extensive remodeling of the pulmonary circulation, leading to severe right …

Vascular smooth muscle cells (SMCs) are circumferentially oriented perpendicular to the
blood vessel and maintain the contractile phenotype in physiological conditions. They can …