In blood vessels, vascular smooth muscle cells (VSMCs) generally exist in two major
phenotypes: contractile and non-contractile (synthetic). The contractile phenotype is …

Smooth muscle is increasingly recognized as a key mechanical sculptor of epithelia during
embryonic development. Smooth muscle is a mesenchymal tissue that surrounds the …

Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs
accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors …

Key points This study demonstrates and evaluates the changes in rat vascular smooth
muscle cell biomechanics following statin‐mediated cholesterol depletion. Evidence is …

Objective: Abdominal aortic aneurysms (AAAs) are highly lethal diseases without effective
clinical predictors and therapeutic targets. Vascular microcalcification, as detected by …

About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the
prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia …

The vasculature consists of vessels of different sizes that are arranged in a hierarchical
pattern. Two cell populations work in concert to establish this pattern during embryonic …

Retinoic acid is a metabolic product derived from vitamin A, acting at a nuclear level to
maintain the proper transcriptional activity. Moreover, this molecule contributes to the …

Construction of an artificial vascular graft is widely considered a promising strategy in
vascular tissue engineering. However, limited sources of functional vascular smooth muscle …

miR-149-5p Inhibits Vascular Smooth Muscle Cells Proliferation, Invasion, and Migration by
Targeting Histone Deacetylase 4 (HDAC4) - PMC Back to Top Skip to main content NIH NLM …