Emerging role of immune cells as drivers of pulmonary fibrosis

SE Mutsaers, T Miles, CM Prêle, GF Hoyne - Pharmacology & Therapeutics, 2023 - Elsevier
The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …

[HTML][HTML] Alveolar Organoids in Lung Disease Modeling

E Purev, K Bahmed, B Kosmider - Biomolecules, 2024 - mdpi.com
Lung organoids display a tissue-specific functional phenomenon and mimic the features of
the original organ. They can reflect the properties of the cells, such as morphology, polarity …

[HTML][HTML] PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice

LR Rodriguez, SY Tang, WR Barboza, A Murthy… - JCI insight, 2023 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a chronic parenchymal lung disease characterized by
repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix …

Transcriptomics Analysis Identifies the Decline in the AT2 Stem Cell Niche in Aged Human Lungs

X Liu, X Zhang, C Yao, J Liang, PW Noble… - American Journal of …, 2024 - atsjournals.org
Aging poses a global public health challenge, which is linked to the rise of age-related lung
diseases. The precise understanding of the molecular and genetic changes in the aging …

[HTML][HTML] Unraveling the mechanism of ethyl acetate extract from Prismatomeris connata YZ Ruan root in treating pulmonary fibrosis: insights from bioinformatics …

S Li, G Hu, L Kuang, T Zhou, H Jiang, F Pang… - Frontiers in …, 2024 - frontiersin.org
Introduction Pulmonary fibrosis is a terminal lung disease characterized by fibroblast
proliferation, extracellular matrix accumulation, inflammatory damage, and tissue structure …

[HTML][HTML] Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis

JF Calver, NR Parmar, G Harris, RM Lithgo… - Journal of Biological …, 2024 - ASBMB
Integrin-mediated activation of the profibrotic mediator transforming growth factor-β1 (TGF-
β1), plays a critical role in idiopathic pulmonary fibrosis (IPF) pathogenesis. Galectin-3 is …

[HTML][HTML] It takes two peroxisome proliferator-activated receptors (PPAR-β/δ and PPAR-γ) to tango idiopathic pulmonary fibrosis

E Boateng, R Bonilla-Martinez, B Ahlemeyer… - Respiratory …, 2024 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung epithelial
phenotypes, fibroblast activation, and increased extracellular matrix deposition …

[HTML][HTML] m6A modification in non-coding RNAs: Mechanisms and potential therapeutic implications in fibrosis

Y Zhou, N Jian, C Jiang, J Wang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Abstract N6-methyladenosine (m 6 A) is one of the most prevalent and reversible forms of
RNA methylation, with increasing evidence indicating its critical role in numerous …

Accumulated inflammation and fibrosis participate in atrazine induced ovary toxicity in mice

YF Yang, SY Cheng, YL Wang, ZP Yue, YX Yu… - Environmental …, 2024 - Elsevier
Atrazine is a widely used herbicide in agricultural production. Previous studies have shown
that atrazine affects hormone secretion and oocyte maturation in female reproduction …

[HTML][HTML] Single-cell RNA-Seq reveals the heterogeneity of fibroblasts within the tympanojugular paraganglioma microenvironment

S Wang, B Zhang, Z Lou, Y Hu, J Wang, J Wang… - Heliyon, 2024 - cell.com
Tympanojugular paragangliomas (TJP) originate from the parasympathetic ganglia in the
lateral base of the skull. Although the cellular composition and oncogenic mechanisms of …