The microbiota plays a fundamental role on the induction, training, and function of the host
immune system. In return, the immune system has largely evolved as a means to maintain …

Chronic inflammation represents one of the most consistent biologic features of aging.
However, the precise etiology of persistent low-grade increases in inflammation remains …

The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and
disease activity. While this has mainly been studied in the context of the bacterial …

In the last 10 years, we have learned much about the pathogenesis, diagnosis, and
management of intestinal fibrosis in patients with inflammatory bowel diseases. Just a …

Background: The diagnosis of pediatric-onset inflammatory bowel disease (PIBD) can be
challenging in choosing the most informative diagnostic tests and correctly classifying PIBD …

Many recent studies have shown that the gut microbiome plays important roles in human
physiology and pathology. Also, microbiome-based therapies have been used to improve …

The predominantly anaerobic microbiota of the distal ileum and colon contain an
extraordinarily complex variety of metabolically active bacteria and fungi that intimately …

Fecal and serologic biomarkers can be used in the diagnosis and management of
inflammatory bowel disease (IBD). Fecal markers such as calprotectin and lactoferrin have …

This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focused
on prediction, diagnosis, and management of fibrostenosing Crohn's disease [CD]. The …

Background & Aims A better understanding of prognostic factors within the heterogeneous
spectrum of pediatric Crohn's disease (CD) should improve patient management and reduce …