Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a
condition consisting of a combination of altered vasomotion and long-term structural change …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Accumulating evidence has shown that diabetes accelerates aging and endothelial cell
senescence is involved in the pathogenesis of diabetic vascular complications, including …

Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia; these are also a combination of …