Diabetic retinopathy (DR) and diabetic macular edema (DME) are retinal complications of
diabetes that can lead to loss of vision and impaired quality of life. The current gold standard …

Western diet-induced obesity is linked to the development of metabolic dysfunctions,
including type 2 diabetes and complications that include retinopathy, a leading cause of …

Studies have demonstrated that polymorphic variants of arginase 1 gene (ARG1) are
involved in human diseases, such as coronary heart disease, hypertension, and diabetes …

Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction
(VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is …

Diabetic kidney disease (DKD) is among the most common and serious complications of
both type 1 and type 2 diabetes. In this study, we used KK/Ta‐Ins2Akita (KK‐Akita) mice as a …

Emerging evidence suggests that arginase contributes to endothelial dysfunction in
diabetes. Intracellular signaling pathways, which interplay between arginase and eNOS …

Purpose: Retinal vasomotor activity can be regulated by two major endothelial enzymes,
nitric oxide synthase (NOS) and cyclooxygenase (COX). The vascular arginase also …

Diabetic retinopathy (DR) is a common diabetic complication that severely impacts the life
quality of diabetic patients. Recently, cellular senescence in human retinal endothelial cells …

Background Arterial stiffness (AS) is an independent risk factor for cardiovascular
morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen …

Neurodegeneration is an initial process in the development of diabetic retinopathy (DR).
High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system …