The emergence of nanotechnology applied to medicine has revolutionized the treatment of
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …

Background Modulating the epigenome has long been considered a potential opportunity
for therapeutic intervention in numerous disease areas with several approved therapies …

We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …

Immunotherapy is a promising approach to treating various types of cancers, including
hepatocellular carcinoma (HCC). While single immunotherapy drugs show limited …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

Abstract Epigenetic (“above genetics”) modifications can alter the gene expression without
altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA …

Background RNA modifications are important regulators of transcript activity and an
increasingly emerging body of data suggests that the epitranscriptome and its associated …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Reprograming the N 6-methyladenosine (m6A) landscape is a promising therapeutic
strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) …

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells
under different environmental stimuli. Bone-resorbing osteoclasts are derived from the …