Secretin is secreted by S cells in the small intestine and affects the function of a number of
organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several …

G protein-coupled receptors (GPCRs) play pivotal roles in regulating the function and
plasticity of neuronal circuits in the nervous system. Among the myriad of GPCRs expressed …

Innate social investigation behaviors are critical for animal survival and are regulated by
both neural circuits and neuroendocrine factors. Our understanding of how neuropeptides …

Secretin (Sct) is released into the circulation postprandially from the duodenal S-cells. The
major functions of Sct originated from the gastrointestinal system are to delay gastric …

Bariatric surgery is currently the most effective therapeutic modality through which sustained
beneficial effects on weight loss and metabolic improvement are achieved. During recent …

Secretin is a peptide hormone released from the duodenum to stimulate the secretion of
digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the …

In mammals, the timing of behavior and physiological activity is controlled by the
suprachiasmatic nucleus (SCN) in the hypothalamus. Incidentally, secretin is a peptide …

The discovery of secretin initiated the field of endocrinology. Over the past century, multiple
gastrointestinal functions of secretin have been extensively studied, and it was discovered …

Secretin (Sct), traditionally a gastrointestinal hormone backed by a century long research, is
now beginning to be recognized also as a neuroactive peptide. Substantiation by recent …

Secretin is a gut peptide hormone that is also expressed in the CNS. To explore the potential
neuroactive role of secretin in the brain, we have generated secretin deficient mice. Secretin …