Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated
cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ …

Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …

Background While schizophrenia differs between males and females in the age of onset,
symptomatology, and disease course, the molecular mechanisms underlying these …

An increasing number of gene expression quantitative trait locus (eQTL) studies have made
summary statistics publicly available, which can be used to gain insight into complex human …

Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but the role of
exosomes in schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation of …

The recognition that schizophrenia is a disorder of neurodevelopment is widely accepted.
The original hypothesis was coined more than 30 years ago and the wealth of supportive …

Over the past decade, large-scale genetic studies have successfully identified hundreds of
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …

The classical M1/M2 polarity of macrophages may not be applicable to inflammatory lung
diseases including chronic obstructive pulmonary disease (COPD) due to the complex …

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders and a
leading cause of disability worldwide. Though recent genome-wide association studies …