A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression
Y Li, C Ma, W Li, Y Yang, X Li, J Liu, J Wang, S Li… - Molecular …, 2021 - nature.com
Genome-wide association studies (GWASs) have revealed that genetic variants at the
22q13. 2 risk locus were robustly associated with schizophrenia. However, the causal …
22q13. 2 risk locus were robustly associated with schizophrenia. However, the causal …
Copy number variant risk scores associated with cognition, psychopathology, and brain structure in youths in the Philadelphia neurodevelopmental cohort
A Alexander-Bloch, G Huguet, LM Schultz… - JAMA …, 2022 - jamanetwork.com
Importance Psychiatric and cognitive phenotypes have been associated with a range of
specific, rare copy number variants (CNVs). Moreover, IQ is strongly associated with CNV …
specific, rare copy number variants (CNVs). Moreover, IQ is strongly associated with CNV …
[HTML][HTML] Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression
Risk-taking behaviour is an important component of several psychiatric disorders, including
attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two …
attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two …
Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder
W Li, X Cai, HJ Li, M Song, CY Zhang, Y Yang… - …, 2021 - nature.com
Genetic analyses for bipolar disorder (BD) have achieved prominent success in Europeans
in recent years, whereas its genetic basis in other populations remains relatively less …
in recent years, whereas its genetic basis in other populations remains relatively less …
[HTML][HTML] Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features,
including differential symptomatology, drug responsiveness, and male incidence rate. Prior …
including differential symptomatology, drug responsiveness, and male incidence rate. Prior …
[HTML][HTML] eQTL Catalogue 2023: New datasets, X chromosome QTLs, and improved detection and visualisation of transcript-level QTLs
The eQTL Catalogue is an open database of uniformly processed human molecular
quantitative trait loci (QTLs). We are continuously updating the resource to further increase …
quantitative trait loci (QTLs). We are continuously updating the resource to further increase …
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development
Remarkable advances have been made in schizophrenia (SCZ) GWAS, but gleaning
biological insight from these loci is challenging. Genetic influences on gene expression (eg …
biological insight from these loci is challenging. Genetic influences on gene expression (eg …
Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations
A Gordon, A Forsingdal, IV Klewe, J Nielsen… - Molecular …, 2021 - nature.com
Genetic risk for psychiatric illness is complex, so identification of shared molecular pathways
where distinct forms of genetic risk might coincide is of substantial interest. A growing body …
where distinct forms of genetic risk might coincide is of substantial interest. A growing body …
Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review
Following the recent review by Merikangas et al.[1] summarizing differential gene
expression in schizophrenia, we wanted to provide readers with our perspective on the state …
expression in schizophrenia, we wanted to provide readers with our perspective on the state …
[HTML][HTML] Allele-specific analysis reveals exon-and cell-type-specific regulatory effects of Alzheimer's disease-associated genetic variants
Elucidating regulatory effects of Alzheimer's disease (AD)-associated genetic variants is
critical for unraveling their causal pathways and understanding the pathology. However …
critical for unraveling their causal pathways and understanding the pathology. However …