The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …

Chemotherapy, radiotherapy, targeted therapy, and immunotherapy have brought hope to
cancer patients. With the prolongation of survival of cancer patients and increased clinical …

Angiogenesis is one of the hallmarks of cancer and a crucial requisite in the development of
tumors. Interrupting this process by blocking the vascular endothelial growth factor (VEGF) …

Renal cell carcinoma (RCC) represents the main renal tumors and are highly metastatic.
Sunitinib, a recently-approved, multi-targeted Tyrosine Kinases Inhibitor (TKi), prolongs …

Immune checkpoints blockades have shown promising clinical effects in various
malignancies, but the overall response rate is low. Here, the immune features are …

Background Neutralization of vascular endothelial growth factor receptor 1 (VEGFR1) and/or
VEGFR2 is a widely used means of inhibiting tumor angiogenesis. Methods Based on the …

The blockade of tumour vascularisation and angiogenesis continues to be a focus for drug
development in oncology and other pathologies. Historically, targeting vascular endothelial …

Introduction Toxicity of chemotherapy drugs is the leading cause of poor therapeutic
outcome in many cancer patients. Gastrointestinal (GI) toxicity and hepatotoxicity are among …