What do cell adhesion, cell migration during embryogenesis, thrombosis, and lymphocyte
help and killing have in common? It has recently become clear that these ostensibly …

By David R. Phillips, Israel F. Charo, Leslie V. Parise, and Laurence A. Fitzgerald A NEW
FAMILY of cell-surface receptors has been identified that mediates a wide variety of cell-cell …

Platelet activation is accompanied by the appearance on the platelet surface of
approximately 45,000 receptor sites for fibrinogen. The binding of fibrinogen to these …

We describe the isolation, characterization, and sequence of cDNA clones encoding one
subunit of the complex of membrane glycoproteins that forms part of the transmembrane …

We have investigated the composition and function of membrane microparticles released
from platelets exposed to the C5b-9 proteins of the complement system. Gel-filtered human …

Activation of human platelets by complement proteins C5b-9 is accompanied by the release
of small plasma membrane vesicles (microparticles) that are highly enriched in binding sites …

Platelets may become activated in a number of clinical disorders and participate in thrombus
formation. We developed a direct test for activated platelets in whole blood using flow …

A large number of glycoprotein (GP) IIb/IIIa receptors are present on the surface of platelets.
Studies to define precisely the number of GPIIb/IIIa receptors using specific monoclonal …

Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …