Summary The Lancet Commission on pollution and health reported that pollution was
responsible for 9 million premature deaths in 2015, making it the world's largest …

The need for assembled existing and new toxicity data has accelerated as the amount of
chemicals introduced into commerce continues to grow and regulatory mandates require …

Climate change, biodiversity loss, and chemical pollution are planetary‐scale emergencies
requiring urgent mitigation actions. As these “triple crises” are deeply interlinked, they need …

New approach methodologies (NAMs) are increasingly being used for regulatory decision
making by agencies worldwide because of their potential to reliably and efficiently produce …

Daphnia magna is one of the most commonly used model organism to assess toxicity of
wide range of pharmaceuticals such as antibiotics, anticancer drugs, antidepressants, anti …

While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …

Safety sciences must cope with uncertainty of models and results as well as information
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …

This paper presents a 10-step read-across (RAX) framework for use in cases where a
threshold of toxicological concern (TTC) approach to cosmetics safety assessment is not …

Nanoplastics (NP) are an emerging threat to human health and there is a need to
understand their toxicity. Zebrafish (ZF) is extensively used as a toxicology model due to its …