[HTML][HTML] Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Roles of peroxisome proliferator-activated receptor gamma on brain and peripheral inflammation

S Villapol - Cellular and molecular neurobiology, 2018 - Springer
Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

MK Ahmmed, F Ahmmed, H Tian… - … Reviews in Food …, 2020 - Wiley Online Library
For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

[HTML][HTML] The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

S Tyagi, P Gupta, AS Saini, C Kaushal… - Journal of advanced …, 2011 - journals.lww.com
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of nuclear hormone receptor superfamily comprising of the following three subtypes …

Alzheimer's disease: strategies for disease modification

M Citron - Nature reviews Drug discovery, 2010 - nature.com
Alzheimer's disease is the largest unmet medical need in neurology. Current drugs improve
symptoms, but do not have profound disease-modifying effects. However, in recent years …

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

SM de la Monte - Current Alzheimer Research, 2012 - ingentaconnect.com
Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Omega‐3 fatty acids for the treatment of dementia

M Burckhardt, M Herke, T Wustmann… - Cochrane Database …, 2016 - cochranelibrary.com
Background Omega‐3 polyunsaturated fatty acids (omega‐3 PUFAs) from fish and plant
sources are commonly considered as a promising non‐medical alternative to improve brain …

[PDF][PDF] Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation

C Turnquist, BT Harris, CC Harris - Neuro-oncology advances, 2020 - academic.oup.com
Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …

[HTML][HTML] Localization of PPAR isotypes in the adult mouse and human brain

A Warden, J Truitt, M Merriman, O Ponomareva… - Scientific reports, 2016 - nature.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act
as ligand-activated transcription factors. PPAR agonists have well-documented anti …

[HTML][HTML] The endocannabinoid system and PPARs: Focus on their signalling crosstalk, action and transcriptional regulation

FA Iannotti, RM Vitale - Cells, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …