Virus‐like particles as powerful vaccination strategy against human viruses

I Hadj Hassine, M Ben M'hadheb… - Reviews in Medical …, 2024 - Wiley Online Library
Nowadays, viruses are not only seen as causative agents of viral infectious diseases but
also as valuable research materials for various biomedical purposes, including recombinant …

[HTML][HTML] The next-generation DNA vaccine platforms and delivery systems: Advances, challenges and prospects

B Lu, JM Lim, B Yu, S Song, P Neeli… - Frontiers in …, 2024 - frontiersin.org
Vaccines have proven effective in the treatment and prevention of numerous diseases.
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …

[HTML][HTML] Translational challenges and prospective solutions in the implementation of biomimetic delivery systems

Z Wang, X Wang, W Xu, Y Li, R Lai, X Qiu, X Chen… - Pharmaceutics, 2023 - mdpi.com
Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems,
have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled …

Advanced nanoscale delivery systems for mRNA-based vaccines

M Mobasher, R Ansari, AM Castejon, J Barar… - Biochimica et Biophysica …, 2024 - Elsevier
The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for
COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of …

[HTML][HTML] Virus-based biological systems as next-generation carriers for the therapy of central nervous system diseases

I Nowak, M Madej, J Secemska, R Sarna… - Pharmaceutics, 2023 - mdpi.com
Central nervous system (CNS) diseases are currently a major challenge in medicine. One
reason is the presence of the blood–brain barrier, which is a significant limitation for …

[HTML][HTML] From organ preservation to selective surgery: How immunotherapy changes colorectal surgery?

S Yao, H Lan, Y Han, C Mao, M Yang, X Zhang… - Surgery Open …, 2023 - Elsevier
The emergence of immunotherapy has revolutionized the traditional treatment paradigm of
colorectal cancer (CRC). Among them, immune checkpoint blockade has become the first …

Recent Advances, Approaches and Challenges in the Development of Universal Influenza Vaccines

CML Lim, TV Komarasamy… - Influenza and Other …, 2024 - Wiley Online Library
Every year, influenza virus infections cause significant morbidity and mortality worldwide.
They pose a substantial burden of disease, in terms of not only health but also the economy …

[HTML][HTML] Heparin-affinity chromatography is a generic purification platform for chimeric gag VLPs displaying different viral surface antigens

AM Zollner, LG Ruiz, V Mayer, S Stohl, LA Jakob… - Separation and …, 2024 - Elsevier
Chimeric virus-like particles formed by the co-expression of HIV-1 gag capsid protein and
surface proteins from other viruses can be used as a platform for production of a wide range …

[HTML][HTML] Virus-like particles based on the novel goose parvovirus (NGPV) VP2 protein protect ducks against NGPV challenge

Y Shang, Y Ma, S Tang, X Chen, H Feng, L Li, H Wang… - Vaccines, 2023 - mdpi.com
Novel goose parvovirus (NGPV), a genetic variant of goose parvovirus, has been spreading
throughout China since 2015 and mainly infects ducklings with the symptoms of growth …

Nucleic Acid Delivery Nanotechnologies for In Vivo Cell Programming

HV Balcorta, VG Contreras Guerrero… - ACS Applied Bio …, 2024 - ACS Publications
In medicine, it is desirable for clinicians to be able to restore function and imbue novel
function into selected cells for therapy and disease prevention. Cells damaged by disease …