A global picture: therapeutic perspectives for COVID-19
VP Chavda, C Kapadia, S Soni, R Prajapati… - …, 2022 - Future Medicine
The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global …
coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global …
[HTML][HTML] Artificial intelligence technologies for COVID-19 de novo drug design
The recent covid crisis has provided important lessons for academia and industry regarding
digital reorganization. Among the fascinating lessons from these times is the huge potential …
digital reorganization. Among the fascinating lessons from these times is the huge potential …
[HTML][HTML] Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors
Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic that caused serious
global emergency. To identify new and effective therapeutics, we employed a drug …
global emergency. To identify new and effective therapeutics, we employed a drug …
[HTML][HTML] Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail
SS Alkhayyat, HM Al-Kuraishy, AI Al-Gareeb… - Inflammation …, 2022 - Springer
Introduction Fenofibrate is an agonist of peroxisome proliferator activated receptor alpha
(PPAR-α), that possesses anti-inflammatory, antioxidant, and anti-thrombotic properties …
(PPAR-α), that possesses anti-inflammatory, antioxidant, and anti-thrombotic properties …
[HTML][HTML] The Delta and Omicron variants of SARS-CoV-2: what we know so far
The world has not yet completely overcome the fear of the havoc brought by SARS-CoV-2.
The virus has undergone several mutations since its initial appearance in China in …
The virus has undergone several mutations since its initial appearance in China in …
[HTML][HTML] Computational prediction of the effect of mutations in the receptor-binding domain on the interaction between SARS-CoV-2 and human ACE2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19
continues to mutate. Numerous studies have indicated that this viral mutation, particularly in …
continues to mutate. Numerous studies have indicated that this viral mutation, particularly in …
[HTML][HTML] Mapping CircRNA–miRNA–mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 …
Non-coding RNAs (ncRNAs) can control the flux of genetic information; affect RNA stability
and play crucial roles in mediating epigenetic modifications. A number of studies have …
and play crucial roles in mediating epigenetic modifications. A number of studies have …
[HTML][HTML] Drug repurposing against main protease and RNA-dependent RNA polymerase of SARS-CoV-2 using molecular docking, MM-GBSA calculations and …
AO Mohammed, MI Abo-Idrees, AA Makki… - Structural Chemistry, 2022 - Springer
A virus called severe acute respiratory distress syndrome coronavirus type 2 (SARS‐CoV‐2)
is the causing organism of coronavirus disease 2019 (COVID-19), which has severely …
is the causing organism of coronavirus disease 2019 (COVID-19), which has severely …
[HTML][HTML] Novel covalent and non-covalent complex-based pharmacophore models of SARS-CoV-2 main protease (Mpro) elucidated by microsecond MD simulations
Y Hayek-Orduz, AF Vásquez, MF Villegas-Torres… - Scientific Reports, 2022 - nature.com
As the world enters its second year of the pandemic caused by SARS-CoV-2, intense efforts
have been directed to develop an effective diagnosis, prevention, and treatment strategies …
have been directed to develop an effective diagnosis, prevention, and treatment strategies …
De novo generation of dual-target ligands for the treatment of SARS-CoV-2 using deep learning, virtual screening, and molecular dynamic simulations
De novo generation of molecules with the necessary features offers a promising opportunity
for artificial intelligence, such as deep generative approaches. However, creating novel …
for artificial intelligence, such as deep generative approaches. However, creating novel …