Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …

Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …

Background The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-
TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring …

Metabolic reprogramming in cancer and immune cells occurs to support their increasing
energy needs in biological tissues. Here we propose Single Cell Spatially resolved …

Based on the structural and signaling roles of cholesterol, which are necessary for immune
cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant …

Simple Summary Squalene synthase is a key enzyme that not only participates in the
mevalonate pathway, resulting in cholesterol, but also acts as a potential ferroptosis …

Simple Summary Receptor tyrosine kinases probably constitute the most important
subfamily of transmembrane receptors with respect to their role in regulating the balance …

Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate
pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an …

Cancer cells alter mechanical tension in their cell membranes. New interventions to regulate
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …

Tumor cells exhibit altered cholesterol content. However, cholesterol structural subcellular
distribution and implication in cancer cell invasion are poorly understood mainly due to …