Heterogeneity and polygenicity in psychiatric disorders: a genome-wide perspective
Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …
disorders and revealed a complex polygenic architecture linking mental and physical health …
Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint
M Ikeda, T Saito, T Kanazawa, N Iwata - Journal of Human Genetics, 2021 - nature.com
Genome-wide association studies (GWASs) have detected many susceptible variants for
common diseases, including psychiatric disorders. However, because of the small effect size …
common diseases, including psychiatric disorders. However, because of the small effect size …
[HTML][HTML] Recent developments in autism genetic research: A scientometric review from 2018 to 2022
Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …
Modeling the complex genetic architectures of brain disease
The genetic architecture of each individual comprises common and rare variants that, acting
alone and in combination, confer risk of disease. The cell-type-specific and/or context …
alone and in combination, confer risk of disease. The cell-type-specific and/or context …
[HTML][HTML] Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation
Background With the rapid development of long-read sequencing technologies, it is possible
to reveal the full spectrum of genetic structural variation (SV). However, the expensive cost …
to reveal the full spectrum of genetic structural variation (SV). However, the expensive cost …
[HTML][HTML] Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the …
Genetic testing has evolved rapidly over recent years and new developments have the
potential to provide insights that could improve the ability to diagnose, treat, and prevent …
potential to provide insights that could improve the ability to diagnose, treat, and prevent …
[HTML][HTML] Brain structural associations with depression in a large early adolescent sample (the ABCD study®)
Background Depression is the leading cause of disability worldwide with> 50% of cases
emerging before the age of 25 years. Large-scale neuroimaging studies in depression …
emerging before the age of 25 years. Large-scale neuroimaging studies in depression …
Gene expression changes following chronic antipsychotic exposure in single cells from mouse striatum
A Abrantes, P Giusti-Rodriguez, NE Ancalade… - Molecular …, 2022 - nature.com
Schizophrenia is an idiopathic psychiatric disorder with a high degree of polygenicity.
Evidence from genetics, single-cell transcriptomics, and pharmacological studies suggest an …
Evidence from genetics, single-cell transcriptomics, and pharmacological studies suggest an …
[HTML][HTML] Restoring the missing person to personalized medicine and precision psychiatry
Precision psychiatry has emerged as part of the shift to personalized medicine and builds on
frameworks such as the US National Institute of Mental Health Research Domain Criteria …
frameworks such as the US National Institute of Mental Health Research Domain Criteria …
Three decades of ASD genetics: building a foundation for neurobiological understanding and treatment
KW Eyring, DH Geschwind - Human Molecular Genetics, 2021 - academic.oup.com
Methodological advances over the last three decades have led to a profound transformation
in our understanding of the genetic origins of neuropsychiatric disorders. This is exemplified …
in our understanding of the genetic origins of neuropsychiatric disorders. This is exemplified …