[HTML][HTML] Metal ions in insect reproduction: a crosstalk between reproductive physiology and immunity

V Cardoso-Jaime, NA Broderick… - Current opinion in insect …, 2022 - Elsevier
Highlights•Metal ions affect reproductive physiology in hematophagous and
nonhematophagous insects.•Metal-homeostasis mechanisms may be shared between …

Modifying mosquitoes to suppress disease transmission: Is the long wait over?

JR Powell - Genetics, 2022 - academic.oup.com
For more than 50 years it has been a dream of medical entomologists and public health
workers to control diseases like malaria and dengue fever by modifying, through genetics …

[HTML][HTML] Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality

S Dong, G Dimopoulos - Nature communications, 2023 - nature.com
Ae. aegypti mosquitoes transmit some of the most important human viral diseases that are
responsible for a significant public health burden worldwide. The small interfering RNA …

[HTML][HTML] RNAi-mediated CHS-2 silencing affects the synthesis of chitin and the formation of the peritrophic membrane in the midgut of Aedes albopictus larvae

C Zhang, Y Ding, M Zhou, Y Tang, R Chen, Y Chen… - Parasites & …, 2023 - Springer
Background Mosquitoes are an important vector of viral transmission, and due to the
complexity of the pathogens they transmit, vector control may be the most effective strategy …

[HTML][HTML] Long non-coding RNAs regulate Aedes aegypti vector competence for Zika virus and reproduction

A Belavilas-Trovas, S Tastsoglou, S Dong, M Kefi… - PLoS …, 2023 - journals.plos.org
Long non-coding RNAs (lncRNAs) play critical regulatory roles in various cellular and
metabolic processes in mosquitoes and all other organisms studied thus far. In particular …

[HTML][HTML] Use of insect promoters in genetic engineering to control mosquito-borne diseases

V Bottino-Rojas, AA James - Biomolecules, 2022 - mdpi.com
Mosquito transgenesis and gene-drive technologies provide the basis for developing
promising new tools for vector-borne disease prevention by either suppressing wild …

[HTML][HTML] The role of mosquito hemocytes in viral infections

V Cardoso-Jaime, CV Tikhe, S Dong, G Dimopoulos - Viruses, 2022 - mdpi.com
Insect hemocytes are the only immune cells that can mount a humoral and cellular immune
response. Despite the critical involvement of hemocytes in immune responses against …

[HTML][HTML] CRISPR/Cas advancements for genome editing, diagnosis, therapeutics, and vaccine development for Plasmodium parasites, and genetic engineering of …

L Nourani, AA Mehrizi, S Pirahmadi… - Infection, Genetics and …, 2023 - Elsevier
Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …

[HTML][HTML] mosGILT controls innate immunity and germ cell development in Anopheles gambiae

G Arora, X Tang, Y Cui, J Yang, YM Chuang, J Joshi… - BMC genomics, 2024 - Springer
Gene-edited mosquitoes lacking ag amma-i nterferon-inducible l ysosomal thiol reductase-
like protein, namely (mosGILT null) have lower Plasmodium infection, which is linked to …

Machine learning techniques for predicting malaria: Unpacking emerging challenges and opportunities for tackling malaria in sub-saharan Africa

E Mbunge, RC Milham, MN Sibiya… - Computer Science On …, 2023 - Springer
Malaria resurgence significantly threatens progress made towards malaria elimination in the
past years and consequently increases socioeconomic and public health burden, especially …