Genome-wide association studies (GWAS) have identified genetic variants at 34 loci
contributing to age-related macular degeneration (AMD),–. We generated transcriptional …

Major depressive disorder emerges from the complex interactions of biological systems that
span genes and molecules through cells, networks, and behavior. Establishing how …

The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Maternal immune activation (MIA), be it triggered by infectious or noninfectious stimuli, is
implicated in various psychiatric and neurological disorders with developmental etiologies …

There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …

Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …

Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …