In the developing brain, immature synapses contain calcium-permeable AMPA glutamate
receptors (AMPARs) that are subsequently replaced with GluA2-containing calcium …

Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

The underlying cell types mediating predisposition to obesity remain largely obscure. Here,
we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

Hundreds of heritable traits and diseases that are caused by germline aberrations in
ubiquitously expressed genes manifest in a remarkably limited number of cell types and …

Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …

Importance Three-dimensional cerebral organoids generated from patient-derived induced
pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings …

Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic
variants have been defined only in a fairly small subset of cases. The enormous genetic …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Individuals with schizophrenia (SZ) exhibit cognitive performance below expected levels
based on familial cognitive aptitude. One such cognitive process, working memory (WM), is …