Changed synapse density has been suggested to be involved in the altered brain
connectivity underlying schizophrenia (SCZ) pathology. However, postmortem studies …

Noncoding variants of presumed regulatory function contribute to the heritability of
neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten …

This article casts a critical eye over the development of American psychiatry from 1980 to the
present. It notes the rapid decline of psychoanalysis that followed the publication of DSM III; …

Chemokines are known to be immunoregulatory proteins involved not only in lymphocyte
chemotaxis to the site of inflammation, but also in neuromodulation, neurogenesis, and …

Identifying the mechanisms through which genetic risk causes dementia is an imperative for
new therapeutic development. Here, we apply a multistage, systems biology approach to …

Multiple psychiatric disorders have been associated with abnormalities in both the innate
and adaptive immune systems. The role of these abnormalities in pathogenesis, and …

The power of human induced pluripotent stem cell (hiPSC)-based studies to resolve the
smaller effects of common variants within the size of cohorts that can be realistically …

Astrocytes are a heterogeneous population of neural cells with diverse structural, functional
and molecular characteristics responsible for homeostasis and protection of the central …

It is widely held that schizophrenia involves an active process of peripheral inflammation that
induces or reflects brain inflammation with activation of microglia, the brain's resident …

Biological studies of bipolar disorder initially focused on the mechanism of action for
antidepressants and antipsychotic drugs, and the roles of monoamines (eg, serotonin …