Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

Transforming growth factor β (TGF-β) has long been implicated in fibrotic diseases, including
the multisystem fibrotic disease systemic sclerosis (SSc). Expression of TGF-β-regulated …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to
repair injured cardiac tissues and regulate pathological fibrosis. However, scalable …

In systemic sclerosis (SSc), a common and aetiologically mysterious form of scleroderma
(defined as pathological fibrosis of the skin), previously healthy adults acquire fibrosis of the …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

Idiopathic pulmonary fibrosis is a fatal lung disease characterized by progressive and
excessive accumulation of myofibroblasts and in the lung. Connective-tissue growth factor …

In recent decades, there have been tremendous improvements in burn care that have
allowed patients to survive severe burn injuries that were once fatal. However, a major …

Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the
main symptoms of OA. At this moment the underlying mechanism of OA-related synovial …