Severe mycobacterial immune reconstitution inflammatory syndrome (IRIS) in advanced human immunodeficiency virus (HIV) has features of hemophagocytic …

JM Rocco, E Laidlaw, F Galindo… - Clinical Infectious …, 2023 - academic.oup.com
Background People with HIV and mycobacterial infections can develop immune
reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART) …

Macrophage activation syndrome in systemic juvenile idiopathic arthritis

M Shimizu - Immunological Medicine, 2021 - Taylor & Francis
Macrophage activation syndrome (MAS) is a severe, potentially life-threatening complication
of systemic juvenile idiopathic arthritis (s-JIA). An immunological feature is the excessive …

From bench to bedside and back again: translational research in autoinflammation

D Holzinger, C Kessel, A Omenetti… - Nature Reviews …, 2015 - nature.com
Translational research approaches brought major changes to the understanding and
treatment options of autoinflammatory diseases. Patients with common complex …

Macrophage activation syndrome

S Deane, ME Gershwin - The Rose and Mackay Textbook of Autoimmune …, 2024 - Elsevier
Macrophage activation syndrome or MAS, known by several names, is an acute severe
inflammatory syndrome that is often secondary to multiple autoimmune and …

Mechanism-based precision therapy for the treatment of primary immunodeficiency and primary immunodysregulatory diseases

JW Leiding, LR Forbes - The Journal of Allergy and Clinical Immunology: In …, 2019 - Elsevier
Advances in understanding the mechanism, immunobiology, and pathophysiology of
primary immunodeficiency diseases have created opportunities for the use of precision …

Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: a study of 20 Moroccan adult patients

A Wafa, H Hicham, R Naoufal, K Hajar, R Rachid… - Clinical …, 2022 - Springer
Objective The objective of this study was to describe the clinical and laboratory
manifestations, triggers factors, treatment, and outcome of MAS complicating SLE. Methods …

Hemophagocytic lymphohistiocytosis

J Skinner, B Yankey, BK Shelton - AACN advanced critical care, 2019 - AACN
Hemophagocytic lymphohistiocytosis is a life-threatening condition associated with
hyperinflammation and multiple organ dysfunction. It has many causes, symptoms, and …

Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

M Takakura, M Shimizu, H Irabu, N Sakumura… - Clinical …, 2019 - Elsevier
Our study aimed to compare the accuracy of serum biomarkers for the diagnosis of
macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s …

Low Percentage of Perforin-Expressing NK Cells during Severe SARS-CoV-2 Infection: Consumption Rather than Primary Deficiency

L Kundura, R Cezar, E Ballongue, S André… - The Journal of …, 2024 - journals.aai.org
Study design All patients were diagnosed as being SARS-CoV-2-infected by RT-PCR. Their
blood was drawn on the first day of hospitalization at an intensive care unit (ICU) or a non …

Advances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets?

P Ruscitti, P Cipriani, P Di Benedetto… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Macrophage activation syndrome (MAS) is a severe, hyperinflammatory life-
threatening syndrome, generally complicating different rheumatic diseases. Despite the …