JL Mega, W Hochholzer, AL Frelinger, MJ Kluk… - Jama, 2011 - jamanetwork.com
Context Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. Objective …
F Andreotti, B Rocca, S Husted, RA Ajjan… - European heart …, 2015 - academic.oup.com
Contemporary medicine is shifting towards person rather than disease-oriented care. 1 With increasing life expectancy and the ageing of baby boomers, the proportion over 60 years is …
S Yusuf, SR Mehta, S Chrolavicius… - JAMA: Journal of …, 2006 - search.ebscohost.com
Context Despite many therapeutic advances, mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) remains high. The role of additional antithrombotic …
JN Smith, JM Negrelli, MB Manek… - The Journal of the …, 2015 - Am Board Family Med
Acute coronary syndrome (ACS) describes the range of myocardial ischemic states that includes unstable angina, non-ST elevated myocardial infarction (MI), or ST-elevated MI …
AD Michelson - Nature Reviews Drug Discovery, 2010 - nature.com
Antiplatelet therapy has been successful in reducing mortality and morbidity in acute myocardial infarction. Recent advances in understanding the molecular basis of the role of …
MM Gonzalez, S Timerman… - Arquivos brasileiros de …, 2013 - SciELO Brasil
Esta edição traz as Diretrizes Brasileiras sobre o Manejo da Ressuscitação Cardiopulmonar (RCP). Embora a ressuscitação tenha uma longa história que remonta aos tempos bíblicos …
Background—Age is an important determinant of outcomes for patients with acute coronary syndromes. However, community practice reveals a disproportionately lower use of …
OBJECTIVE: Dual antiplatelet therapy with clopidogrel plus acetylsalicylic acid (ASA) is superior to ASA alone in patients with acute coronary syndromes and in those undergoing …
JL Ferreiro, DJ Angiolillo - Circulation, 2011 - Am Heart Assoc
Cardiovascular disease, particularly coronary artery dis-ease resulting from accelerated atherosclerosis, is the leading cause of morbidity and mortality in patients with diabetes …