Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary …

SMH Mahmud, M Al-Mustanjid, F Akter… - Briefings in …, 2021 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), better known as
COVID-19, has become a current threat to humanity. The second wave of the SARS-CoV-2 …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

[HTML][HTML] Deep learning-based molecular dynamics simulation for structure-based drug design against SARS-CoV-2

Y Sun, Y Jiao, C Shi, Y Zhang - Computational and structural biotechnology …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2), has led to a global pandemic. Deep learning …

Weighted gene co-expression network analysis combined with machine learning validation to identify key modules and hub genes associated with SARS-CoV-2 …

H Karami, A Derakhshani, M Ghasemigol… - Journal of clinical …, 2021 - mdpi.com
The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives.
Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless …

Cutaneous manifestations related to the COVID-19 pandemic: a review article

H Molaee, F Allahyari, SN Emadi… - Cutaneous and Ocular …, 2021 - Taylor & Francis
Background Skin lesions are either caused by COVID-19 disease or they can be due to
other driving forces related to the COVID-19 pandemic. Aim Considering the fact that the …

Target-centered drug repurposing predictions of human angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) …

Y Choi, B Shin, K Kang, S Park, BR Beck - Viruses, 2020 - mdpi.com
Previously, our group predicted commercially available Food and Drug Administration (FDA)
approved drugs that can inhibit each step of the replication of severe acute respiratory …

Anti-viral activity of bioactive molecules of silymarin against COVID-19 via in silico studies

C Zhang, Y Sui, S Liu, M Yang - Pharmaceuticals, 2023 - mdpi.com
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection drove the
global coronavirus disease 2019 (COVID-19) pandemic, causing a huge loss of human life …

Deepdrug: a general graph‐based deep learning framework for drug‐drug interactions and drug‐target interactions prediction

Q Yin, R Fan, X Cao, Q Liu, R Jiang… - Quantitative …, 2023 - Wiley Online Library
Computational methods for DDIs and DTIs prediction are essential for accelerating the drug
discovery process. We proposed a novel deep learning method DeepDrug, to tackle these …

Network pharmacology-based analysis of Zukamu granules for the treatment of COVID-19

Y Zeng, G Lou, Y Ren, T Li, X Zhang, J Wang… - European journal of …, 2021 - Elsevier
Introduction Zukamu granules may play a potential role in the fight against the Coronavirus,
COVID-19. The purpose of this study was to explore the mechanisms of Zukamu granules …

Lung Deposition Using the Respimat® Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An In Vitro/In Silico Analysis

AM Ciciliani, M Denny, P Langguth… - COPD: Journal of …, 2020 - Taylor & Francis
Tiotropium and olodaterol are mainstay treatments for chronic obstructive pulmonary
disease (COPD) and yield important clinical improvements, especially when used in fixed …