SARS‐CoV‐2: A comprehensive review from pathogenicity of the virus to clinical consequences

M Lotfi, N Rezaei - Journal of medical virology, 2020 - Wiley Online Library
Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which caused
novel coronavirus disease (COVID‐19) pandemic, is the worldwide challenge. The virus is …

First case of drug‐induced liver injury associated with the use of tocilizumab in a patient with COVID‐19

D Muhović, J Bojović, A Bulatović, B Vukčević… - Liver …, 2020 - Wiley Online Library
Abstract Background and Aims Tocilizumab (TCZ; interleukine‐6 receptor antagonist) has
been proposed to treat severe forms of Coronavirus disease‐19 (COVID‐19) because …

Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19

AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …

Coronavirus disease 2019 (COVID-19) as a multi-systemic disease and its impact in low-and middle-income countries (LMICs)

MN Temgoua, FT Endomba, JR Nkeck… - SN comprehensive …, 2020 - Springer
Currently, the coronavirus disease 2019 (COVID-19) is the priority of the global health
agenda. Since the first case was reported in Wuhan, China, this infection has continued to …

Considerations around the SARS-CoV-2 spike protein with particular attention to COVID-19 brain infection and neurological symptoms

K Hassanzadeh, H Perez Pena, J Dragotto… - ACS chemical …, 2020 - ACS Publications
Spike protein (S protein) is the virus “key” to infect cells and is able to strongly bind to the
human angiotensin-converting enzyme2 (ACE2), as has been reported. In fact, Spike …

[HTML][HTML] Hyperinflammation and fibrosis in severe COVID-19 patients: galectin-3, a target molecule to consider

J Garcia-Revilla, T Deierborg, JL Venero… - Frontiers in …, 2020 - frontiersin.org
COVID-19 disease have become so far the most important sanitary crisis in the XXI century.
In light of the events, any clinical resource should be considered to alleviate this crisis …

Cytokine storm in COVID‐19 patients, its impact on organs and potential treatment by QTY code‐designed detergent‐free chemokine receptors

MI Mustafa, AH Abdelmoneim… - Mediators of …, 2020 - Wiley Online Library
The novel coronavirus is not only causing respiratory problems, but it may also damage the
heart, kidneys, liver, and other organs; in Wuhan, 14 to 30% of COVID‐19 patients have lost …

[HTML][HTML] Potential cross-reactive immunity to SARS-CoV-2 from common human pathogens and vaccines

PA Reche - Frontiers in immunology, 2020 - frontiersin.org
The recently emerged SARS-CoV-2 causing the ongoing COVID-19 pandemic is particularly
virulent in the elderly while children are largely spared. Here, we explored the potential role …

Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection

LEB Galan, NM Santos, MS Asato… - Pathogens and global …, 2021 - Taylor & Francis
Objective: Given the urgent need for strategies to minimize the damage caused by this
pandemic, this study performed a randomized, double-blind phase 2 study to assess the …

[HTML][HTML] Repurposing anticancer drugs for the management of COVID-19

K El Bairi, D Trapani, A Petrillo, C Le Page… - European Journal of …, 2020 - Elsevier
Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded …