The field of reverse vaccinology developed as an outcome of the genome sequence
revolution. Following the introduction of live vaccinations in the western world by Edward …

Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-
chimeric VLP-based vaccines are highly successful licensed products (eg, hepatitis B …

Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito,
when they are ingested in an infectious blood meal. Here, we determine the transmission …

Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the
interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich …

Although epidemiological observations, IgG passive transfer studies and experimental
infections in humans all support the feasibility of developing highly effective malaria …

Though the immunity to malaria has been associated with cellular immune responses, the
exact function of the phenotypic cell population is still unclear. This study investigated the …

Genome-scale mutagenesis screens for genes essential for apicomplexan parasite survival
have been completed in three species: Plasmodium falciparum, the major human malaria …

A large body of evidence supports the role of antibodies directed against the Plasmodium
spp. parasite in the development of naturally acquired immunity to malaria, however an …

Plasmodium gametocytes are the sexual forms of the malaria parasite essential for
transmission to mosquitoes. To better understand how gametocytes differ from asexual …

Genomics and bioinformatics are increasingly contributing to our understanding of infectious
diseases caused by bacterial pathogens such as Mycobacterium tuberculosis and parasites …