Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Stabilization and reusability of enzyme transglutaminase (TGM) are important goals for the
enzymatic process since immobilizing TGM plays an important role in different technologies …

Background Bone metastasis is the leading cause of death in patients with prostate cancer
(PCa) and currently has no effective treatment. Disseminated tumor cells in bone marrow …

Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular
patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of …

Background: The immunotherapy sensitivity of patients with bladder cancer (BCa) remains
low. As the role of protein methylation in tumorigenesis and development becomes clearer …

Protein post-translational modification (PTM) is a regulatory mechanism for protein activity
modulation, localization, expression, and interactions with other cellular molecules. It …

As critical executors regulating many cellular operations, proteins determine whether living
activities can be performed in an orderly and efficient manner. Precursor proteins are inert …

Genetic instability can be caused by external factors and may also be associated with
intracellular damage. At the same time, there is a large body of research investigating the …

Abstract Targeted Protein Modification (TPM) is an umbrella term encompassing numerous
tools and approaches that use bifunctional agents to induce a desired modification over the …