Lifestyle interventions for the prevention and treatment of hypertension

PL Valenzuela, P Carrera-Bastos, BG Gálvez… - Nature Reviews …, 2021 - nature.com
Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

Role of the immune system in hypertension

B Rodriguez-Iturbe, H Pons… - Physiological …, 2017 - journals.physiology.org
High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Deficiency of prebiotic fiber and insufficient signaling through gut metabolite-sensing receptors leads to cardiovascular disease

DM Kaye, WA Shihata, HA Jama, K Tsyganov… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) continues to be a major, poorly controlled but
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …

[HTML][HTML] Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis

M Nazarzadeh, Z Bidel, D Canoy, E Copland, M Wamil… - The Lancet, 2021 - thelancet.com
Background Blood pressure lowering is an established strategy for preventing microvascular
and macrovascular complications of diabetes, but its role in the prevention of diabetes itself …

Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Bacterial infections and patterns of antibiotic use in patients with COVID‐19

A Goncalves Mendes Neto, KB Lo… - Journal of medical …, 2021 - Wiley Online Library
Bacterial coinfection is associated with poor outcomes in patients with viral pneumonia, but
data on its role in the mortality of patients with coronavirus disease 2019 (COVID‐19) is …

Hypertension meets osteoarthritis—revisiting the vascular aetiology hypothesis

K Ching, X Houard, F Berenbaum, C Wen - Nature Reviews …, 2021 - nature.com
Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion
abnormalities and neovascular invasion into the synovium and articular cartilage. In addition …

Arterial hypertension and interleukins: potential therapeutic target or future diagnostic marker?

DM Tanase, EM Gosav, S Radu… - International journal …, 2019 - Wiley Online Library
Hypertension as a multifactorial pathology is one of the most important cardiovascular risk
factors, affecting up to 30‐40% of the general population. Complex immune responses are …

Usual blood pressure and risk of new-onset diabetes: evidence from 4.1 million adults and a meta-analysis of prospective studies

CA Emdin, SG Anderson, M Woodward… - Journal of the American …, 2015 - jacc.org
Background: Reliable quantification of the association between blood pressure (BP) and risk
of type 2 diabetes is lacking. Objectives: This study sought to determine the association …

Inflammation and hypertension: new understandings and potential therapeutic targets

C De Miguel, NP Rudemiller, JM Abais… - Current hypertension …, 2015 - Springer
Research studying the role of inflammation in hypertension and cardiovascular disease has
flourished in recent years; however, the exact mechanisms by which the activated immune …