Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC …

Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant,
pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained …

When plants recognize potential opponents, invading pathogens, wound signals, or abiotic
stress, they often switch to a primed state of enhanced defense. However, defense priming …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Among other effects, post-translational modifications (PTMs) have been shown to exert their
function via the modulation of protein-protein interactions. For twelve different main PTM …

Chemical modifications of histones and DNA, such as histone methylation, histone
acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of …

Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …

Chromatin regulation is essential to regulate genes and genome activities. In plants, the
alteration of histone modification and DNA methylation are coordinated with changes in the …

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of
H3F3A, one of the two genes encoding histone H3 variant H3. 3, in 60% of high-grade …