Glutamate carboxypeptidase II (GCPII) is a membrane-bound binuclear zinc
metallopeptidase with the highest expression levels found in the nervous and prostatic …

In the progress of science, as in life, timing is important. The acidic dipeptide, N‐
acetylaspartylglutamate (NAAG), was discovered in the mammalian nervous system in 1965 …

Intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic cystic neoplasm
that is often invasive and metastatic, resulting in a poor prognosis. Few molecular alterations …

Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells
and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and …

We recently identified agamma-interferon-induciblelysosomal thiol reductase (GILT),
constitutively expressed in antigen-presenting cells, that catalyzes disulfide bond reduction …

Arabidopsis amp1 mutants show pleiotropic phenotypes, including altered shoot apical
meristems, increased cell proliferation, polycotyly, constitutive photomorphogenesis, early …

The function of MHC class II molecules is to bind peptides derived from antigens that access
the endocytic route of antigen presenting cells and display them on the plasma membrane …

Hepatocellular carcinoma (HCC) is a common primary cancer associated frequently with
hepatitis C virus (HCV). To gain insight into the molecular mechanisms of …

Sialidase (neuraminidase), encoded by theneu-1 gene in the major histocompatibility
complex locus catalyzes the intralysosomal degradation of sialylated glycoconjugates …

The peptide neurotransmitter N‐acetylaspartylglutamate is inactivated by extracellular
peptidase activity following synaptic release. It is speculated that the enzyme, glutamate …