Breast cancer is a common cancer affecting a large number of patients. Notably, 5–10% of
all breast cancer patients are genetically predisposed to cancers. Although the most …

BRCA1 and BRCA2 germline mutations contribute to a significant number of familial and
hereditary breast and/or ovarian cancers. The proportion of high-risk families with breast …

BACKGROUND It is believed that BRCA1 and BRCA2 germline mutations account for the
majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are …

Purpose Risk-reducing salpingo-oophorectomy (RRSO) has been widely adopted as a key
component of breast and gynecologic cancer risk-reduction for women with BRCA1 and …

Introduction BRCA gene mutations are associated with hereditary ovarian cancer. BRCA
plays a key role in genome integrity, and mutations result in an increased risk for ovarian …

To elucidate the mechanisms of rapid progression of serous ovarian cancer, gene
expression profiles from 43 ovarian cancer tissues comprising eight early stage and 35 …

Approximately 5%–10% of breast cancers are due to genetic predisposition caused by
germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations …

Breast and ovarian cancer represent two of the most common tumor types in females
worldwide. Over the years, several non‑modifiable and modifiable risk factors have been …

Hereditary breast and ovarian cancer is caused by a germline mutation in BRCA1 or BRCA2
genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline …

Background Ethnic variations in breast cancer epidemiology and genetics have
necessitated investigation of the spectra of BRCA1 and BRCA2 mutations in different …