[HTML][HTML] The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies

B Hassani, Z Attar, N Firouzabadi - Cancer Cell International, 2023 - Springer
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

[HTML][HTML] Repurposing of chronically used drugs in cancer therapy: a chance to grasp

MA Hijazi, A Gessner, N El-Najjar - Cancers, 2023 - mdpi.com
Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

[HTML][HTML] The mechanisms of renin–angiotensin system in hepatocellular carcinoma: From the perspective of liver fibrosis, HCC cell proliferation, metastasis and …

HF Zhang, X Gao, X Wang, X Chen, Y Huang… - Biomedicine & …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, of which
the occurrence and development involve a variety of pathophysiological processes, such as …

[HTML][HTML] The effect of local renin angiotensin system in the common types of cancer

M Almutlaq, AA Alamro, HS Alamri… - Frontiers in …, 2021 - frontiersin.org
The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood
pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it …

The role of vascular endothelial cells in tumor metastasis

Y Feng, S Luo, D Fan, X Guo, S Ma - Acta Histochemica, 2023 - Elsevier
Vascular endothelial cells (VECs) are an integral component of the inner lining of blood
vessels, and their functions are essential for the proper functioning of the vascular system …

[HTML][HTML] In Vitro Drug Repurposing: Focus on Vasodilators

E Ribeiro, B Costa, F Vasques-Nóvoa, N Vale - Cells, 2023 - mdpi.com
Drug repurposing aims to identify new therapeutic uses for drugs that have already been
approved for other conditions. This approach can save time and resources compared to …

[HTML][HTML] RAAS: a convergent player in ischemic heart failure and cancer

TC Garcia-Garduño, JR Padilla-Gutierrez… - International journal of …, 2021 - mdpi.com
The current global prevalence of heart failure is estimated at 64.34 million cases, and it is
expected to increase in the coming years, especially in countries with a medium-low …

[HTML][HTML] Effect of PLC-β1/CaM signaling pathway mediated by AT1R on the occurrence and development of hepatocellular carcinoma

Z Xu, N Liu, X Wang, B Ding, H Zhang, Y Li… - Cancer cell …, 2021 - Springer
Objective To study the roles of AT1R, PLC-β1, CaM and other related signal molecules in
the formation and development of hepatocellular carcinoma (HCC) and their correlation …

Genetic Variations Related to Angiotensin II Production and Risk for Basal Cell Carcinoma

I Gintoni, M Mastrogeorgiou, V Papakosta… - Biochemical …, 2024 - Springer
Basal cell carcinoma (BCC) is the most prevalent human neoplasm, with constantly
increasing annual incidence. Despite its slow growth, BCC is locally invasive and, if left …

Construction of endothelial cell‐related and autophagy‐related prognostic models for hepatocellular carcinoma based on single‐cell data

L Mou, K Li, C Xu, I Xu, Y Yang… - … of Gastroenterology and …, 2023 - Wiley Online Library
Background We aimed to develop an autophagy‐related prognostic model with single‐cell
RNA sequencing (ScRNA‐Seq) data for hepatocellular carcinoma (HCC) patients. Methods …