Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours, including differentiation, migration and proliferation, through mechanotransduction. Studies …
JK Gustafsson, MEV Johansson - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestinal tract faces numerous challenges that require several layers of defence. The tight epithelium forms a physical barrier that is further protected by a mucus layer, which …
INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that have enormous potential as models for human organ development and disease, as …
Organotypic models of patient-specific tumours are revolutionizing our understanding of cancer heterogeneity and its implications for personalized medicine. These advancements …
Three-dimensional (3D) bioprinting techniques have emerged as the most popular methods to fabricate 3D-engineered tissues; however, there are challenges in simultaneously …
Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized …
Understanding human organ formation is a scientific challenge with far-reaching medical implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
W Kim, Y Gwon, S Park, H Kim, J Kim - Bioactive Materials, 2023 - Elsevier
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable attention as a way to better mimic the complex interactions between individual cells and the …
Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables the study of host–microbe interactions with great experimental control. This protocol …