Introduction: Not enough data exist to inform the optimal duration and type of antimicrobial
therapy against GN infections in critically ill patients. Methods: Narrative review based on a …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

In patients that are admitted to intensive care units (ICUs), the clinical outcome of severe
infections depends on several factors, as well as the early administration of chemotherapies …

Therapeutic drug monitoring (TDM) is a critical clinical tool used to optimize the safety and
effectiveness of drugs by measuring their concentration in biological fluids. These fluids are …

Patients in intensive care units (ICU) are at high risk to experience potential drug-drug
interactions (pDDIs) because of the complexity of their drug regimens. Such pDDIs may be …

Dalbavancin (DBV) is a lipoglycopeptide approved for the treatment of Gram-positive
infections of the skin and skin-associated structures (ABSSSIs). Currently, its off-label use at …

Dalbavancin is a long-acting lipoglycopeptide that is registered for the treatment of acute
bacterial skin and skin structure infections, and it is also increasingly used for infections that …

Here, we describe the use of proactive therapeutic drug monitoring (TDM) to individualize
the optimal timing of drug injections in 16 adult patients with chronic osteoarticular infections …

The outcome for critically ill patients is burdened by a double mortality rate and a longer
hospital stay in the case of sepsis or septic shock. The adequate use of antibiotics may …

Background: Antibiotic dosing adaptation in elderly patients is frequently complicated by age-
related changes affecting the processes of drug absorption, distribution, metabolism, and/or …