Emerging technologies for molecular diagnosis of sepsis

M Sinha, J Jupe, H Mack, TP Coleman… - Clinical microbiology …, 2018 - Am Soc Microbiol
Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Inflammation and preterm birth

M Cappelletti, S Della Bella, E Ferrazzi… - Journal of Leucocyte …, 2016 - academic.oup.com
Preterm birth is the leading cause of neonatal morbidity and mortality. Although the
underlying causes of pregnancy-associated complication are numerous, it is well …

Viable bacterial colonization is highly limited in the human intestine in utero

E Rackaityte, J Halkias, EM Fukui, VF Mendoza… - Nature medicine, 2020 - nature.com
Mucosal immunity develops in the human fetal intestine by 11–14 weeks of gestation, yet
whether viable microbes exist in utero and interact with the intestinal immune system is …

[HTML][HTML] Preterm birth associated with maternal fine particulate matter exposure: A global, regional and national assessment

CS Malley, JCI Kuylenstierna, HW Vallack… - Environment …, 2017 - Elsevier
Reduction of preterm births (< 37 completed weeks of gestation) would substantially reduce
neonatal and infant mortality, and deleterious health effects in survivors. Maternal fine …

[HTML][HTML] Mechanisms of fetal T cell tolerance and immune regulation

E Rackaityte, J Halkias - Frontiers in immunology, 2020 - frontiersin.org
The developing human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …

The clinical use of corticosteroids in pregnancy

MW Kemp, JP Newnham, JG Challis… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND The use of antenatal steroid therapy is common in pregnancy. In early
pregnancy, steroids may be used in women for the treatment of recurrent miscarriage or fetal …

[HTML][HTML] Preterm birth: Inflammation, fetal injury and treatment strategies

AK Boyle, SF Rinaldi, JE Norman, SJ Stock - Journal of reproductive …, 2017 - Elsevier
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and
accounts for approximately 11% of births worldwide. Premature babies are at risk of a …

Spontaneous preterm birth: advances toward the discovery of genetic predisposition

JF Strauss III, R Romero, N Gomez-Lopez… - American journal of …, 2018 - Elsevier
Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

SS Zhou, YH Tao, K Huang, BB Zhu… - Journal of Obstetrics …, 2017 - Wiley Online Library
Aim We performed a meta‐analysis of randomized controlled trials (RCT) and observational
studies to answer the two following questions:(i) whether low maternal circulating 25 …

Intrauterine infection, immune system and premature birth

FR Helmo, EAR Alves, RAA Moreira… - The journal of …, 2018 - Taylor & Francis
Preterm birth accounts for nearly one million deaths among children under five years of age,
and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection …