A new, potent, and placenta-permeable macrolide antibiotic, solithromycin, for the prevention and treatment of bacterial infections in pregnancy

JA Keelan, MS Payne, MW Kemp, DJ Ireland… - Frontiers in …, 2016 - frontiersin.org
Intrauterine infection–inflammation is a major cause of early preterm birth and subsequent
neonatal mortality and acute or long-term morbidity. Antibiotics can be administered in …

Congenital infection influence on early brain development through the gut-brain Axis

GW Kirschen, S Panda, I Burd - Frontiers in Neuroscience, 2022 - frontiersin.org
The mechanisms by which various pathogens cause congenital infections have been
studied extensively, aiding in the understanding of the detrimental effects these infections …

In search of new paradigms for epididymal health and disease: innate immunity, inflammatory mediators, and steroid hormones

MCW Avellar, CM Ribeiro, MR Dias-da-Silva… - …, 2019 - Wiley Online Library
The primary job of the epididymis is to mature and protect the luminally transiting
spermatozoa. Mounting evidence is showing that innate immune components [including Toll …

Downregulation of miR-21 is involved in the pathogenesis of infection-induced preterm birth by targeting NF-κB

L Duan, J Wang, R Shuai, C Qu, M Qin, Y Cong… - Reproductive …, 2022 - Springer
Infection-induced preterm birth (PTB) is contributing to the main factors of increased
maternal and fetal morbidity and mortality. Infections and inflammation are often …

[HTML][HTML] Racial disparity in placental pathology in the collaborative perinatal project

Y Chen, L Huang, H Zhang, M Klebanoff… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Objective: There is substantial disparity in perinatal outcomes between white and African-
American women, but the underlying biological mechanisms are poorly understood. The …

Association of intraplacental oxygenation patterns on dual‐contrast MRI with placental abnormality and fetal brain oxygenation

Z Sun, W Wu, P Zhao, Q Wang… - … in Obstetrics & …, 2023 - Wiley Online Library
Objectives Most human in‐vivo placental imaging techniques are unable to distinguish and
characterize various placental compartments, such as the intervillous space (IVS), placental …

Преждевременные роды: прошлые ограничения и новые возможности

КА Горина, ЗС Ходжаева, ДМ Белоусов… - Акушерство и …, 2020 - elibrary.ru
Проведены поиск и анализ данных мировой литературы, посвященной исследованию
инфекционновоспалительного фактора как ведущего в генезе преждевременных …

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep

M Nikiforou, MW Kemp, RH Van Gorp, M Saito… - Laboratory …, 2016 - nature.com
Chorioamnionitis, caused by intra-amniotic exposure to bacteria and their toxic components,
is associated with fetal gut inflammation and mucosal injury. In a translational ovine model …

Causal role of group B Streptococcus-induced acute chorioamnionitis in intrauterine growth retardation and cerebral palsy-like impairments

MJ Allard, ME Brochu, JD Bergeron… - … Origins of Health and …, 2019 - cambridge.org
Chorioamnionitis and intrauterine growth retardation (IUGR) are risk factors for cerebral
palsy (CP). Common bacteria isolated in chorioamnionitis include group B Streptococcus …

The significance of TNF‐α and MMP‐8 concentrations in non‐invasively obtained amniotic fluid predicting fetal inflammatory response syndrome

V Gulbiniene, G Balciuniene… - … of Gynecology & …, 2023 - Wiley Online Library
Objective To determine the significance of tumor necrosis factor‐α (TNF‐α) and matrix
metalloproteinase‐8 (MMP‐8) in vaginally obtained amniotic fluid predicting fetal …