[HTML][HTML] Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and …
Abstract The SARS-CoV-2 papain-like protease (PL pro) and main protease (M pro) are
nucleophilic cysteine enzymes that catalyze the hydrolysis of the viral polyproteins …
nucleophilic cysteine enzymes that catalyze the hydrolysis of the viral polyproteins …
Screening Peptide Drug Candidates To Neutralize Whole Viral Agents: A Case Study with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
CE Özçelik, CZ Araz, O Yılmaz… - ACS Pharmacology & …, 2024 - ACS Publications
The COVID-19 pandemic revealed the need for therapeutic and pharmaceutical molecule
development in a short time with different approaches. Although boosting immunological …
development in a short time with different approaches. Although boosting immunological …
Inhibition of SARS-CoV-2 Nsp9 ssDNA-Binding Activity and Cytotoxic Effects on H838, H1975, and A549 Human Non-Small Cell Lung Cancer Cells: Exploring the …
HH Su, ES Lin, YH Huang, Y Lien… - International Journal of …, 2024 - mdpi.com
Carnivorous pitcher plants from the genus Nepenthes are renowned for their ethnobotanical
uses. This research explores the therapeutic potential of Nepenthes miranda leaf extract …
uses. This research explores the therapeutic potential of Nepenthes miranda leaf extract …
A scientific career from the early 1960s till 2023: A tale of the various protagonists
E De Clercq - Biochemical Pharmacology, 2024 - Elsevier
In this era spanning more than 60 years (from the early 1960s till today (2023), a broad
variety of actors played a decisive role: Piet De Somer, Tom C. Merigan, Paul A. Janssen …
variety of actors played a decisive role: Piet De Somer, Tom C. Merigan, Paul A. Janssen …
Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune …
SARS-CoV-2, also referred to as severe acute respiratory syndrome coronavirus 2, is the
virus responsible for causing COVID-19, an infectious disease that emerged in Wuhan …
virus responsible for causing COVID-19, an infectious disease that emerged in Wuhan …
A panel of janus kinase inhibitors identified with anti-inflammatory effects protect mice from lethal influenza virus infection
Y Yu, S Chen, H Zhang, Y Duan, Z Li… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Influenza remains a significant threat to public health. In severe cases, excessive
inflammation can lead to severe pneumonia or acute respiratory distress syndrome …
inflammation can lead to severe pneumonia or acute respiratory distress syndrome …
Emerging anti-spike monoclonal antibodies against SARS-CoV-2
EE Ordaya, RR Razonable - Expert Opinion on Biological Therapy, 2024 - Taylor & Francis
Introduction Anti-spike monoclonal antibodies (mAbs) were previously authorized for the
prevention and treatment of COVID-19 in immunocompromised patients. However, they are …
prevention and treatment of COVID-19 in immunocompromised patients. However, they are …
A Dual Pharmacological Strategy against COVID-19: The Therapeutic Potential of Metformin and Atorvastatin
LA De Jesús-González, RM Del Ángel… - Microorganisms, 2024 - mdpi.com
Metformin (MET) and atorvastatin (ATO) are promising treatments for COVID-19. This review
explores the potential of MET and ATO, commonly prescribed for diabetes and dyslipidemia …
explores the potential of MET and ATO, commonly prescribed for diabetes and dyslipidemia …
Exploring Binding Pockets in the Conformational States of the SARS-CoV-2 Spike Trimers for the Screening of Allosteric Inhibitors Using Molecular Simulations and …
G Gupta, G Verkhivker - International Journal of Molecular Sciences, 2024 - mdpi.com
Understanding mechanisms of allosteric regulation remains elusive for the SARS-CoV-2
spike protein, despite the increasing interest and effort in discovering allosteric inhibitors of …
spike protein, despite the increasing interest and effort in discovering allosteric inhibitors of …
Manidipine is not a potential inhibitor against SARS-CoV-2 main protease
R Zhang, J Zhou, H Yan, X Liu, C Shang… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
The rapid spread of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection highlights an urgent need …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection highlights an urgent need …