Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

CD4+ T cells with cytotoxic activity (CD4 CTL) have been observed in various immune
responses. These cells are characterized by their ability to secrete granzyme B and perforin …

The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform …

CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …

SARS-CoV-2 first emerged in the human population in late 2019 in Wuhan, China, and in a
matter of months, spread across the globe resulting in the Coronavirus Disease 19 (COVID …

A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …

Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology.
Thus, dozens of different animal models of IBD have been developed in past decades …

Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and
correlates of protection from severe dengue disease and vaccine efficacy have not yet been …

TCRαβ thymocytes differentiate into either CD8αβ+ cytotoxic T lymphocytes or CD4+ helper
T cells. This functional dichotomy is controlled by key transcription factors, including the …