The roles of genetic polymorphisms in the pathogenesis of recurrent miscarriage (RM) have
been intensively studied. However, the results of these studies were inconsistent, especially …

Recurrent pregnancy loss (RPL) is a reproductive disorder defined as two or more
successive and spontaneous pregnancy losses (before 20 weeks of gestation), which affects …

Background Thrombophilic gene polymorphism is known to be a risk factor for recurrent
pregnancy loss (RPL), but few studies have confirmed a possible role of thrombophilic …

Recurrent pregnancy loss (RPL) has become an important reproductive health issue
worldwide. RPL affects about 2%–3% of reproductive-aged women, and makes serious …

Published studies indicate the MTHFR C677T and A1298C polymorphisms are associated
with abnormal homocysteine levels, which may cause various pregnancy complications and …

Purpose MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-
nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in …

Recurrent pregnancy loss (RPL) is a common reproductive problem affecting around 5% of
couples worldwide. At present, about half of RPL cases remained unexplained. Previous …

The balance between coagulation and fibrinolysis is an essential part in early pregnancy.
Mutations in methylenetetrahydrofolate reductase (MTHFR) gene lead to decreased activity …

Methylation is a crucially important ubiquitous biochemical process, which covalently adds
methyl groups to a variety of molecular targets. It is the key regulatory process that …

In patients with MTHFR (methylenetetrahydrofolate reductase) mutations and
hyperhomocysteinemia, recurrent pregnancy loss is a frequent feature. The aim of the study …