Nanotechnology-based approaches for effective detection of tumor markers: A comprehensive state-of-the-art review

U Laraib, S Sargazi, A Rahdar, M Khatami… - International Journal of …, 2022 - Elsevier
As well-appreciated biomarkers, tumor markers have been spotlighted as reliable tools for
predicting the behavior of different tumors and helping clinicians ascertain the type of …

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy

A Mafi, M Rezaee, N Hedayati, SD Hogan… - Cell Communication and …, 2023 - Springer
Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

Towards a systems view of IBS

EA Mayer, JS Labus, K Tillisch, SW Cole… - Nature Reviews …, 2015 - nature.com
Despite an extensive body of reported information about peripheral and central mechanisms
involved in the pathophysiology of IBS symptoms, no comprehensive disease model has …

The crucial role of multiomic approach in cancer research and clinically relevant outcomes

M Lu, X Zhan - EPMA Journal, 2018 - Springer
Cancer with heavily economic and social burden is the hot point in the field of medical
research. Some remarkable achievements have been made; however, the exact …

Overall survival prediction of non-small cell lung cancer by integrating microarray and clinical data with deep learning

YH Lai, WN Chen, TC Hsu, C Lin, Y Tsao, S Wu - Scientific reports, 2020 - nature.com
Non-small cell lung cancer (NSCLC) is one of the most common lung cancers worldwide.
Accurate prognostic stratification of NSCLC can become an important clinical reference …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Combination of plasma microRNAs with serum CA19‐9 for early detection of pancreatic cancer

J Liu, J Gao, Y Du, Z Li, Y Ren, J Gu… - … journal of cancer, 2012 - Wiley Online Library
This study was performed to identify plasma microRNAs (miRNAs) as diagnostic biomarkers
for pancreatic cancer (PCa) and to assess their supplementary role with serum CA19‐9 in …

Warburg effect or reverse Warburg effect? A review of cancer metabolism

XD Xu, SX Shao, HP Jiang, YW Cao… - Oncology research and …, 2015 - karger.com
Cancer is a major threat to human health. A considerable amount of research has focused
on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor …

Cancer systems biology: a network modeling perspective

PK Kreeger, DA Lauffenburger - Carcinogenesis, 2010 - academic.oup.com
Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …