[HTML][HTML] Malaria vaccines: recent advances and new horizons
The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity
B Slütter, N Van Braeckel-Budimir, G Abboud… - Science …, 2017 - science.org
Lung-resident memory CD8 T cells (TRM) induced by influenza A virus (IAV) that are pivotal
for providing subtype-transcending protection against IAV infection (heterosubtypic …
for providing subtype-transcending protection against IAV infection (heterosubtypic …
[HTML][HTML] Malaria prevention: from immunological concepts to effective vaccines and protective antibodies
IA Cockburn, RA Seder - Nature immunology, 2018 - nature.com
Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …
[HTML][HTML] Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …
γδ T cells are required for the induction of sterile immunity during irradiated sporozoite vaccinations
I Zaidi, H Diallo, S Conteh, Y Robbins… - The Journal of …, 2017 - journals.aai.org
Whole-sporozoite vaccines confer sterilizing immunity to malaria-naive individuals by
unknown mechanisms. In the first PfSPZ Vaccine trial ever in a malaria-endemic population …
unknown mechanisms. In the first PfSPZ Vaccine trial ever in a malaria-endemic population …
[HTML][HTML] A natural peptide antigen within the plasmodium ribosomal protein RPL6 confers liver TRM cell-mediated immunity against malaria in mice
AM Valencia-Hernandez, WY Ng, N Ghazanfari… - Cell host & …, 2020 - cell.com
Liver-resident memory CD8+ T (T RM) cells remain in and constantly patrol the liver to elicit
rapid immunity upon antigen encounter and can mediate efficient protection against liver …
rapid immunity upon antigen encounter and can mediate efficient protection against liver …
[HTML][HTML] Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
MN Lefebvre, FA Surette, SM Anthony, R Vijay… - Cell reports, 2021 - cell.com
Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria
infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the …
infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the …
[HTML][HTML] Monocyte-derived CD11c+ cells acquire plasmodium from hepatocytes to prime CD8 T cell immunity to liver-stage malaria
Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect
hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria …
hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria …
Host-targeted interventions as an exciting opportunity to combat malaria
Terminal and benign diseases alike in adults, children, pregnant women, and others are
successfully treated by pharmacological inhibitors that target human enzymes. Despite …
successfully treated by pharmacological inhibitors that target human enzymes. Despite …