Epidemic and emerging coronaviruses (severe acute respiratory syndrome and Middle East respiratory syndrome)

DS Hui - Clinics in chest medicine, 2017 - chestmed.theclinics.com
CoVs (order Nidovirales, family Coronaviridae, subfamily Coronavirinae) are a group of
highly diverse, single-stranded, enveloped, positivesense, RNA viruses that may cause …

Antiviral combinations for severe influenza

J Dunning, JK Baillie, B Cao… - The Lancet infectious …, 2014 - thelancet.com
Observational data suggest that the treatment of influenza infection with neuraminidase
inhibitors decreases progression to more severe illness, especially when treatment is started …

[HTML][HTML] Case report: adrenal pathology findings in severe COVID-19: an autopsy study

MF Santana, MGS Borba… - The American journal …, 2020 - ncbi.nlm.nih.gov
Although high mortality has been reported in many COVID-19 studies, very limited
postmortem information from complete autopsies is available. We report the findings in the …

Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow

O Garraud, F Heshmati, B Pozzetto, F Lefrere… - Transfusion Clinique et …, 2016 - Elsevier
Plasma therapy consists in bringing to a patient in need–in general suffering a severe,
resistant to current therapy, and even lethal infection–plasma or specific, fractioned …

The role of adjuvant immunomodulatory agents for treatment of severe influenza

DS Hui, N Lee, PK Chan, JH Beigel - Antiviral research, 2018 - Elsevier
A severe inflammatory immune response with hypercytokinemia occurs in patients
hospitalized with severe influenza, such as avian influenza A (H5N1), A (H7N9), and …

Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options

A Zumla, ZA Memish, M Maeurer, M Bates… - The Lancet Infectious …, 2014 - thelancet.com
The emergence and spread of antimicrobial-resistant bacterial, viral, and fungal pathogens
for which diminishing treatment options are available is of major global concern. New viral …

Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and …

X Jia, B Liu, L Bao, Q Lv, F Li, H Li, Y An… - PLoS …, 2018 - journals.plos.org
Severe influenza A virus infection causes high mortality and morbidity worldwide due to
delayed antiviral treatment and inducing overwhelming immune responses, which contribute …

Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: a randomized controlled trial

N Lee, CK Wong, MCW Chan, ESL Yeung, WWS Tam… - Antiviral research, 2017 - Elsevier
Introduction− Macrolides can ameliorate inflammation in respiratory diseases, providing
clinical benefits. Data in influenza is lacking. Method− A randomized, open-label, multicenter …

Neuraminidase inhibitors, superinfection and corticosteroids affect survival of influenza patients

N Lee, YS Leo, B Cao, PKS Chan… - European …, 2015 - Eur Respiratory Soc
We aimed to study factors influencing outcomes of adults hospitalised for seasonal and
pandemic influenza. Individual-patient data from three Asian cohorts (Hong Kong …

Successful treatment of a centenarian with coronavirus disease 2019 (COVID-19) using convalescent plasma

Y Kong, C Cai, L Ling, L Zeng, M Wu, Y Wu… - … and Apheresis Science, 2020 - Elsevier
Background Because treatment options for coronavirus disease 2019 (COVID-19) are very
limited, the use of convalescent plasma has bee explored. Case presentation and treatment …