Investigating the possible mechanisms of autonomic dysfunction post-COVID-19

M Jammoul, J Naddour, A Madi, MA Reslan… - Autonomic …, 2023 - Elsevier
Patients with long COVID suffer from many neurological manifestations that persist for 3
months following infection by SARS-CoV-2. Autonomic dysfunction (AD) or dysautonomia is …

Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

M Khan, M Clijsters, S Choi, W Backaert, M Claerhout… - Neuron, 2022 - cell.com
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct and short route from
the nose into the brain? We reasoned that the neurotropic or neuroinvasive capacity of the …

Mucosal plasma cells are required to protect the upper airway and brain from infection

SA Wellford, AP Moseman, K Dao, KE Wright, A Chen… - Immunity, 2022 - cell.com
While blood antibodies mediate protective immunity in most organs, whether they protect
nasal surfaces in the upper airway is unclear. Using multiple viral infection models in mice …

[HTML][HTML] Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

JH Jeong, S Chokkakula, SC Min, BK Kim, WS Choi… - Antiviral research, 2022 - Elsevier
As the SARS-CoV-2 pandemic remains uncontrolled owing to the continuous emergence of
variants of concern, there is an immediate need to implement the most effective antiviral …

Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

J Villadiego, J García-Arriaza, R Ramírez-Lorca… - Nature …, 2023 - nature.com
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective
efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18 …

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

Olfactory immune response to SARS-CoV-2

SA Wellford, EA Moseman - Cellular & Molecular Immunology, 2024 - nature.com
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-
2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier …