A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Concepts of extracellular matrix remodelling in tumour progression and metastasis

J Winkler, A Abisoye-Ogunniyan, KJ Metcalf… - Nature …, 2020 - nature.com
Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

The extracellular matrix in development

DAC Walma, KM Yamada - Development, 2020 - journals.biologists.com
As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies

P Rousselle, F Braye, G Dayan - Advanced Drug Delivery Reviews, 2019 - Elsevier
Cutaneous wound healing in adult mammals is a complex multi-step process involving
overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation …

A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

R Jayadev, MRPT Morais, JM Ellingford… - Science …, 2022 - science.org
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

Decellularization for the retention of tissue niches

D Moffat, K Ye, S Jin - Journal of tissue engineering, 2022 - journals.sagepub.com
Decellularization of natural tissues to produce extracellular matrix is a promising method for
three-dimensional scaffolding and for understanding microenvironment of the tissue of …

Cell motility in cancer invasion and metastasis: insights from simple model organisms

CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Extracellular matrix in kidney fibrosis: more than just a scaffold

RD Bülow, P Boor - Journal of Histochemistry & …, 2019 - journals.sagepub.com
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …