Molecular mechanisms of antibiotic resistance revisited

EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

Comparative overview of advanced oxidation processes and biological approaches for the removal pharmaceuticals

N Taoufik, W Boumya, M Achak, M Sillanpää… - Journal of Environmental …, 2021 - Elsevier
Nowadays, pharmaceuticals are the center of significant environmental research due to their
complex and highly stable bioactivity, increasing concentration in the water streams and …

Flourishing antibacterial strategies for osteomyelitis therapy

X Wang, M Zhang, T Zhu, Q Wei, G Liu… - Advanced …, 2023 - Wiley Online Library
Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic
microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis …

Cationic polysaccharide conjugates as antibiotic adjuvants resensitize multidrug‐resistant bacteria and prevent resistance

S Mu, Y Zhu, Y Wang, S Qu, Y Huang… - Advanced …, 2022 - Wiley Online Library
In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of
multidrug‐resistant (MDR) bacteria, which poses severe threat to human life and globalized …

Biocatalytic amide bond formation

M Lubberink, W Finnigan, SL Flitsch - Green Chemistry, 2023 - pubs.rsc.org
Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

Facile Green Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Origanum majorana with Potential Bioactivity against Multidrug Resistant Bacterial …

MT Yassin, AAF Mostafa, AA Al-Askar, FO Al-Otibi - Crystals, 2022 - mdpi.com
The high prevalence of nosocomial bacterial resistance contributes to significant mortality
and morbidity around the world; thus, finding novel antibacterial agents is of vital concern …

Complexes of β-lactam antibiotics and their Schiff-base derivatives as a weapon in the fight against bacterial resistance

M Zabiszak, J Frymark, K Ogawa, M Skrobańska… - Coordination Chemistry …, 2023 - Elsevier
Abstract β-lactam antibiotics are widely used chemical compounds in medicine due to their
strong antibacterial activity. These drugs are produced by fungi (Penicillium …

[HTML][HTML] FDA-approved oximes and their significance in medicinal chemistry

J Dhuguru, E Zviagin, R Skouta - Pharmaceuticals, 2022 - mdpi.com
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a
major threat to humans, accounting for nearly one million poisoning cases every year …

Fabrication of an ultrasensitive electrochemical immunosensor coupled with biofunctionalized zero-dimensional graphene quantum dots for rapid detection of …

P Kolhe, A Roberts, S Gandhi - Food Chemistry, 2023 - Elsevier
The unregulated usage of Cephalexin (CFX) in animal source food products has led to
antimicrobial resistance (AMR) in humans. Graphene quantum dots (GQD) are zero …