Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

Integrins are cell adhesion receptors that are evolutionary old and that play important roles
during developmental and pathological processes. The integrin family is composed of 24 αβ …

Rapid progress has been made in the understanding of the molecular interactions that result
in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood …

This review examines the evidence that platelets play a major role in localizing and
controlling the burst of thrombin generation leading to fibrin clot formation. From the first …

ADHESION IS REQUIRED for cell growth, differentiation, survival, and function. Nowhere is
this more evident than in the response to tissue injury, where vascular damage triggers …

By David R. Phillips, Israel F. Charo, Leslie V. Parise, and Laurence A. Fitzgerald A NEW
FAMILY of cell-surface receptors has been identified that mediates a wide variety of cell-cell …

Platelets have a key role in atherosclerosis, thrombosis, and acute coronary syndromes.
Therapeutic manipulation of platelet function has focused principally on the use of aspirin …

Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

A number of cytoskeletal-associated proteins that are concentrated in focal contacts, namely
alpha-actinin, vinculin, talin, and integrin, have been shown to interact in vitro such that they …

The platelet integrin, glycoprotein IIb-IIIa (GPIIb-IIIa), is a calcium-dependent heterodimer
that binds fibrinogen, von Willebrand factor, and fibronectin after platelet activation. We …