Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …

Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …

For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …

Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

The emergence of ZIKV infection has prompted a global effort to develop safe and effective
vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine …

The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus of significant public health
concern. ZIKV shares a high degree of sequence and structural homology compared with …

Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The
flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major …

Zika virus is a member of the Flavivirus genus that had not been associated with severe
disease in humans until the recent outbreaks, when it was linked to microcephaly in …